Transcriptional autoregulation in development
نویسندگان
چکیده
منابع مشابه
Transcriptional autoregulation in development
reactions. Intermediary metabolism, for example, is run by enzymatic machines that are revved up and down by allosteric responses to the binding of small molecules. And in bacteria we know of one set of genes that is not regulated by recruitment: the inactive promoters bear a special form of tightly-bound RNA polymerase, and the activator uses energy in the form of ATP to turn on transcription....
متن کاملTranscriptional autoregulation controls pancreatic Ptf1a expression during development and adulthood.
The basic helix-loop-helix (bHLH) transcription factor PTF1a is critical to the development of the embryonic pancreas. It is required early for the formation of the undifferentiated tubular epithelium of the nascent pancreatic rudiment and then becomes restricted to the differentiating acinar cells, where it directs the transcriptional activation of the secretory digestive enzyme genes. Here we...
متن کاملTranscriptional autoregulation by BRCA1.
The BRCA1 gene product plays numerous roles in regulating genome integrity. Its role in assembling supermolecular complexes in response to DNA damage has been extensively studied; however, much less is understood about its role as a transcriptional coregulator. Loss or mutation is associated with hereditary breast and ovarian cancers, whereas altered expression occurs frequently in sporadic for...
متن کاملMaintaining a memory by transcriptional autoregulation
One of the key features of cellular differentiation programs is stability. Although differentiation is reversible in principle, many components of the gene batteries induced upon terminal differentiation are maintained throughout a cell's life. For example, muscle cells continuously express the myosin gene, and GABAergic neurons continuously express genes for GABA synthesis and transport. Maint...
متن کاملNegative autoregulation matches production and demand in synthetic transcriptional networks.
We propose a negative feedback architecture that regulates activity of artificial genes, or "genelets", to meet their output downstream demand, achieving robustness with respect to uncertain open-loop output production rates. In particular, we consider the case where the outputs of two genelets interact to form a single assembled product. We show with analysis and experiments that negative auto...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Current Biology
سال: 2009
ISSN: 0960-9822
DOI: 10.1016/j.cub.2009.01.015